《细胞生物学》PPT课件 厦门大学 叶军

 
课件内容： 
Introduction of Molecular cell biology 
Introduction 课堂教学视频 
The objectives and development of cell biology 
Microscope and Cell theory 
Major events in cell biology 
Cell theory-test 
Culturing and visualizing cells 
课下阅读文献：Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus，Nature. 2003 Nov 27;426(6965):450-4 
Growing Cells in Culture 
Monoclonal antibodies 
Fluorescence Microscopy 
Flow cytometry 
Spinning Disk Confocal Microscopy 
FRAP and FRET 
RNA interference 
The structure of CRISPR Cas9 
Mechanism of CRISPR/cas9 
Culturing and visualizing cells-test 
课堂教学视频 
Transmembrane transport of Ions and small molecules 
课堂教学视频 
微课视频：急性腹泻口服补液疗法的作用机制 
Overview of transmembrane transport 
Facilitated Transport of Glucose and Water 
ATP –powered pumps 
Na+/k+ pump 
Ca2+ pump 
K+ channel and the Resting membrane potencial 
Cotransport by Symporters and Antiporters 
Transcellular transport 
Transmembrane transport of Ions and small molecules 
Biomembrane Structure 
课堂教学视频1 
The structrures of the plasmic membrane 
The lipid bilayer: Composition and structural organization 
Forms of lipid molecules exist in water 
Lipids Movement in biomembrane 
Structure of Membrane Proteins 
Synthesis of Phospholipids and Intracellular Movement 
Biomembrane Structure-test 
Cellular Energetics 
课堂教学视频 
课外文献阅读：The molecular machinery of Keilins respiratory chain，Biochem Soc Trans. 2003 Dec;31(Pt 6):1095-105） 
Overview of aerobic oxidation 
Structure of Mitochondria 
Mitochondrial Oxidation of Fatty Acids Generates ATP 
The Electron Carriers and Electron Transport Chain 
The Electron Transport and Generation of the Proton-Motive Force 
Chemiosmotic theory and Endosymbiont hypothesis 
Harnessing the Proton-Motive Force to synthesize ATP 
Electron Transport and Reactive Oxygen Species (ROS) 
Cellular Energetics 
Moving Proteins into Membranes and Organelles 
Targeting of Peroxisomal Proteins 
课堂教学视频 
课下阅读文献：The Cytoplasmic Tail of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Contains a Novel Endoplasmic Reticulum Retrieval Signal That Binds COPI and Promotes Interaction with Membrane Protein 
Targeting Proteins to and Across the ER Membrane 
Insertion of single-pass Proteins into the ER 
Insertion of Multipass Proteins into the ER 
Protein Glycosylation and Folding in the ER 
Formation of disulfide bonds in the ER 
Protein Quality Control in the ER 
Targeting of Proteins to Mitochondria 
Moving Proteins into Membranes and Organelles 
Vesicular traffic,secretion and endocytosis 
Molecular Mechanisms of Vesicle Budding and Fusion 
Early Stages of the Secretory Pathway 
Later Stages of the Secretory Pathway 
Receptor-Mediated Endocytosis 
Directing Membrane Proteins and Cytosolic Materials to the Lysosome 
课堂教学视频 
The structure and functions of Lysosomes 
Vesicular traffic,secretion and endocytosis 
Signal transduction and G protein-coupled receptors 
Brief Introduction of Cell Communication 
Signaling Molecules and Receptors 
G Proteins and G Protein-coupled Receptors (GPCR) 
GPCR Mediated Signaling pathways 
Signal transduction 
Signaling pathways that control gene activity 
Outlines of Signaling pathways that control  gene activity 
Phosphoinositide Signaling Pathways 
TGF-b Receptors and TGFb Signaling Pathways 
Signaling Pathways controlled by Ubiquitination 
The Ras/MAPK and JAK/STAT signaling pathway 
Signaling pathways that control gene activity 
Cell organization and movement I: Microfilaments 
Actin Filaments 
Dynamic Assembly of Actin Filaments 
Actin-Based Cellular Structures 
Myosins and Myosin-Powered Movements 
Cell organization and movement I: Microfilament 
Cell organization and movement II: Microtubules and intermediate filament 
第一单元 Microtubule Structure and Organization 
第二单元 Microtubule Dynamics 
第三单元 Regulation of Microtubule Structure and Dynamics 
第四单元 Kinesins & Dyneins: Microtubule-Based Motor Proteins 
第五单元 Cilia & Flagella: Microtubule-Based Surface Structures 
第六单元 Mitotic Spindle 
第七单元 Intermediate Filaments 
Cell organization and movement II: Microtubules and intermediate filament单元测验 
文献阅读材料 
The Eukaryotic Cell Cycle 
第一单元 Unit 1, Overview of the Cell Cycle and Its Control 
第二单元 Unit 2, Model Organisms to Study the Cell Cycle 
第三单元 Unit 3, CDK and Regulation of CDK Activity 
第四单元 Unit 4, Entry into Cell Cycle (G1-S Transition; START Transition) 
第五单元 Unit 5, Entry into Mitosis (G2-M Transition) 
第六单元 Unit 6, Chromosome Segregation (Metaphase-to-Anaphase Transition) 
第七单元 Unit 7, Cell Cycle Checkpoints (Surveillance Mechanisms) 
第八单元 Unit 8, Cell Cycle and Human Diseases– Cancer & Down Syndrome 
The Eukaryotic Cell Cycle单元测验 
Nucleus, chromatin and chromosomes 
第一单元 Unit 1, Nuclear envelope (NE) & nuclear pore complex (NPC) 
第二单元 Unit 2, Nuclear import and export 
第三单元 Unit 3, Chromatin & Chromosome 
Nucleus, chromatin and chromosomes 单元测验 
Cell senescence and death 
What is senescence? 
Characteristics of senescence 
Molecular mechanism of senescence 
Physio-pathological roles of Senescence 
Cell death 1-apoptosis 
Cell death 2-necroptosis and pyroptosis 
Cell senescence and death 
Slides 
Integrating cells into tissues 
第一单元 Unit 1 cell-cell and cell-matrix adhesion overview 
第二单元 Unit 2 Cell adhesion molecules 
第三单元 Unit 3 Cell-Cell and Cell- ECM junction Part I 
第四单元 Unit 4 Cell-Cell and Cell- ECM junction Part II 
第五单元 Unit 5 Extracellular Matrix 
Ch20 Test -single answer choice 
Stem cells, cell asymmetry 
第一单元 Unit 1 An overview of Stem cells 
第二单元 Unit 2 Embryonic, Adult Stem Cell and Niches 
第三单元 Unit 3 Cell Polarity and Cell Asymetry 
Ch21 Test- single answer Choice